correlation between grade in transitional cell carcinoma (tcc) and expression of epidermal growth factor receptor (egfr)

Authors

mr jallali nadoushan

f heidary

f zaeri

h ahmadi

abstract

background: the present study was undertaken to investigate the correlation of epidermal growth factor receptor (egfr) expression with grade of transitional cell carcinoma (tcc). methods: tumor samples of 75 patients from mostafa khomaini hospital with transitional cell carcinoma of the bladder were analyzed by immunohistochemistry for expression of egfr. in this context, we assigned the bladder tumors a grade accord ing who classification. results analyzed for possible correlation with the expression status of the epidermal growth factor receptor (egfr). results: this cross-sectional study showed that all grades of transitional cell carcinoma expressed egfr, and 14 cases were lmp (18.9%) which 10 cases among them had negative cells according egfr point of view(71.4%) and 4 cases had re ported positive (28.6%). thirty five cases were low grade (46.7%) which 18 cases among them had reported negative cells (51.4%) and 17 cases had positive cells (48.6%). twenty six cases were high grade (34.7%) that 9 cases among them had reported negative cells (34.6%). seventeen cases had positive cells (65.4%). mann-witney test showed relation between grade and expression of egfr (p<0.05). conclusions: this study showed that expression of egfr is correlated with grade of tumor.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Altered Expression of Epidermal Growth Factor Receptor (EGFR) in Glioma

      EGFR is a key molecule in cancer cells. EGFR signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. We extracted proteins from astrocytoma (III and IV) oligodendroglioma(IV) tumors and normal brain tissues and then evaluated the protein purity by Bradford test ...

full text

Epidermal Growth Factor Receptor Expression in Oral Squamous Cell Carcinoma by Immunohistochemical Technique and its Correlation with Clinicopathological Features

Background:Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Despite some improvements in treatment, the survival rate is still very low, mainly due to the possible development of secondary malignancy or metastasis. Clinical and pathological features as well as molecular biomarkers might predict the recurrence. In recent years, many studies ...

full text

Epidermal growth factor receptor expression in canine transitional cell carcinoma

Transitional cell carcinoma (TCC), a urinary bladder tumor with high mortality, is encountered commonly in dogs. Whereas overexpression of epidermal growth factor receptor (EGFR) is associated with development of human urinary bladder cancer, information on EGFR expression in canine TCC is lacking. In this study, EGFR protein and mRNA expression in canine normal bladder (n=5), polypoid cystitis...

full text

altered expression of epidermal growth factor receptor (egfr) in glioma

egfr is a key molecule in cancer cells. egfr signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. we extracted proteins from astrocytoma (iii and iv) oligodendroglioma(iv) tumors and normal brain tissues and then evaluated the protein purity by bradford test and sp...

full text

Breast Carcinoma; Human Epidermal Growth Factor Receptor-2 (HER-2) and Grading Correlation

Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlat...

full text

Epidermal Growth Factor Receptor (EGFR) Expression in Operable Non-small Cell Lung Carcinoma

This study was performed to assay the expression of epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma (NSCLC), and to investigate the relationship between EGFR status and various clinicopathologic features of NSCLC, including angiogenesis and proliferative activity. The expression of EGFR, microvessel count (MVC) measured by CD31 monoclonal antibody, and proliferative act...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of public health

جلد ۳۶، شماره ۲، صفحات ۴۷-۴۹

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023